The Long-Sought-After Salicylic Acid Receptors

β1 integrin is a long-sought sensor for tauroursodeoxycholic acid.

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repai...

Salicylic Acid in Neuralgia

seven grains of the Carbonate of soda, and give you a brief record of my experiences. During the taking of the first dram, there certainly was an abatement of the pain, and of the burning sensation I almost always have on the side of my face and head, and my pulse fell about five beats per minute, that is, from 72 to 68, and sometimes 65. During the taking of the second dram 1 began to experien...

Integrating data on the Arabidopsis NPR1/NPR3/NPR4 salicylic acid receptors; a differentiating argument

Salicylic acid (SA) is a mandatory plant metabolite in the deployment of systemic acquired resistance (SAR), a broad-spectrum systemic immune response induced by local inoculation with avirulent pathogens. The NPR1 transcription co-activator is the central node positively regulating SAR. SA was the last of the major hormones to be without a known receptor. Recently, NPR1 was shown to be the dir...

Salicylic Acid and Aspirin Inhibit the Activity